Paul and Barnabas traveled inland to the high country and reached Pisidian Antioch. This Antioch was in the Roman province of Galatia in Asia Minor. This city is not the same one as the city of Antioch in Syria.
As usual, the apostles began their work at the synagogue (see study note on 9:2; compare 13:5; 14:1; 17:1, 2, 10, 17; 18:4, 19; 19:8).