Despair: Leads to Blasphemy

They will roam the land, dejected and hungry. When they are famished, they will become enraged; and looking upward, they will curse their king and their God.

And the fifth angel poured out his bowl on the throne of the beast, and its kingdom was plunged into darkness, and men began to gnaw their tongues in anguish

…and curse the God of heaven for their pains and sores. Yet they did not repent of their deeds.